Code - CPT/HCPCS | Title (Service/Description) | Pre Service Review Required | Type of Pre Service Review Required | Submit Using | Policy or Criteria Link(s) | Comments |
0001U | Red blood cell antigen typing, DNA, human erythrocyte antigen gene analysis of 35 antigens from 11 blood groups, utilizing whole blood, common RBC alleles reported | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0002M | Liver disease, ten biochemical assays (ALT, A2-macroglobulin, apolipoprotein A-1, total bilirubin, GGT, haptoglobin, AST, glucose, total cholesterol and triglycerides) utilizing serum, prognostic algorithm reported as quantitative scores for fibrosis, steatosis and alcoholic steatohepatitis (ASH) | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0003M | Liver disease, ten biochemical assays (ALT, A2-macroglobulin, apolipoprotein A-1, total bilirubin, GGT, haptoglobin, AST, glucose, total cholesterol and triglycerides) utilizing serum, prognostic algorithm reported as quantitative scores for fibrosis, steatosis and nonalcoholic steatohepatitis (NASH) | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0004M | Scoliosis, DNA analysis of 53 single nucleotide polymorphisms (SNPs), using saliva, prognostic algorithm reported as a risk score | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0005U | Oncology (prostate) gene expression profile by real-time RT-PCR of 3 genes (ERG, PCA3, and SPDEF), urine, algorithm reported as risk score | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0006M | Oncology (hepatic), mRNA expression levels of 161 genes, utilizing fresh hepatocellular carcinoma tumor tissue, with alpha-fetoprotein level, algorithm reported as a risk classifier | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0007M | Oncology (gastrointestinal neuroendocrine tumors), real-time PCR expression analysis of 51 genes, utilizing whole peripheral blood, algorithm reported as a nomogram of tumor disease index | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0007U | Drug test(s), presumptive, with definitive confirmation of positive results, any number of drug classes, urine, includes specimen verification including DNA authentication in comparison to buccal DNA, per date of service | No | N/A | N/A |
Drug Testing in Pain Management and Substance Use Disorder Treatment
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0008U | Helicobacter pylori detection and antibiotic resistance, DNA, 16S and 23S rRNA, gyrA, pbp1, rdxA and rpoB, next-generation sequencing, formalin-fixed paraffin embedded or fresh tissue or fecal sample, predictive, reported as positive or negative for resistance to clarithromycin, fluoroquinolones, metronidazole, amoxicillin, tetracycline, and rifabutin | No | N/A | N/A |
Molecular Testing Vendor Policies
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0008U | Helicobacter pylori detection and antibiotic resistance, DNA, 16S and 23S rRNA, gyrA, pbp1, rdxA and rpoB, next-generation sequencing, formalin-fixed paraffin embedded or fresh tissue or fecal sample, predictive, reported as positive or negative for resistance to clarithromycin, fluoroquinolones, metronidazole, amoxicillin, tetracycline, and rifabutin | No | N/A | N/A |
Plasma-Based Proteomic Screening in the Management of Pulmonary Nodules
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0009U | Oncology (breast cancer), ERBB2 (HER2) copy number by FISH, tumor cells from formalin fixed paraffin embedded tissue isolated using image-based dielectrophoresis (DEP) sorting, reported as ERBB2 gene amplified or non-amplified | No | N/A | N/A |
Molecular Testing Vendor Policies
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0010U | Infectious disease (bacterial), strain typing by whole genome sequencing, phylogenetic-based report of strain relatedness, per submitted isolate | No | N/A | N/A |
Molecular Testing Vendor Policies
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0011M | Oncology, prostate cancer, mRNA expression assay of 12 genes (10 content and 2 housekeeping), RT-PCR test utilizing blood plasma and urine, algorithms to predict high-grade prostate cancer risk | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0011U | Prescription drug monitoring, evaluation of drugs present by LC-MS/MS, using oral fluid, reported as a comparison to an estimated steady-state range, per date of service including all drug compounds and metabolites | No | N/A | N/A |
Drug Testing in Pain Management and Substance Use Disorder Treatment
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0012M | Oncology (urothelial), mRNA, gene expression profiling by real-time quantitative PCR of five genes (MDK, HOXA13, CDC2 [CDK1], IGFBP5, and CXCR2), utilizing urine, algorithm reported as a risk score for having urothelial carcinoma | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0013M | Oncology (urothelial), mRNA, gene expression profiling by real-time quantitative PCR of five genes (MDK, HOXA13, CDC2 [CDK1], IGFBP5, and CXCR2), utilizing urine, algorithm reported as a risk score for having recurrent urothelial carcinoma | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0016M | Oncology (bladder), mRNA, microarray gene expression profiling of 219 genes, utilizing formalin-fixed paraffin-embedded tissue, algorithm reported as molecular subtype (luminal, luminal infiltrated, basal, basal claudin-low, neuroendocrine-like) | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0016U | Oncology (hematolymphoid neoplasia), RNA, BCR/ABL1 major and minor breakpoint fusion transcripts, quantitative PCR amplification, blood or bone marrow, report of fusion not detected or detected with quantitation | No | N/A | N/A |
Molecular Testing Vendor Policies
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0017M | Oncology (diffuse large B-cell lymphoma [DLBCL]), mRNA, gene expression profiling by fluorescent probe hybridization of 20 genes, formalin-fixed paraffinembedded tissue, algorithm reported as cell of origin | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0017U | Oncology (hematolymphoid neoplasia), JAK2 mutation, DNA, PCR amplification of exons 12-14 and sequence analysis, blood or bone marrow, report of JAK2 mutation not detected or detected | No | N/A | N/A |
Molecular Testing Vendor Policies
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0018U | Oncology (thyroid), microRNA profiling by RT-PCR of 10 microRNA sequences, utilizing fine needle aspirate, algorithm reported as a positive or negative result for moderate to high risk of malignancy | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0019U | Oncology, RNA, gene expression by whole transcriptome sequencing, formalin-fixed paraffin embedded tissue or fresh frozen tissue, predictive algorithm reported as potential targets for therapeutic agents | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0020M | "Oncology (central nervous system), analysis of 30000 DNA methylation loci by methylation array, utilizing DNA extracted from tumor tissue, diagnostic algorithm reported as probability of matching a reference tumor
subclass" | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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0021U | Oncology (prostate), detection of 8 autoantibodies (ARF 6, NKX3-1, 5-UTR-BMI1, CEP 164, 3-UTR-Ropporin, Desmocollin, AURKAIP-1, CSNK2A2), multiplexed immunoassay and flow cytometry serum, algorithm reported as risk score | No | N/A | N/A |
Genetic and Protein Biomarkers for the Diagnosis and Cancer Risk Assessment of Prostate Cancer
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0022U | Targeted genomic sequence analysis panel, non-small cell lung neoplasia, DNA and RNA analysis, 23 genes, interrogation for sequence variants and rearrangements, reported as presence or absence of variants and associated therapy(ies) to consider | Yes | Prior Approval | Utilization Management Tool- Procedures and DME |
Molecular Testing Vendor Policies
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